Publications


2020

Lokugamage KG
, Hage A, de Vries Maren, Valero-Jimenez AM, Schindewolf C, Dittmann M, Rajsbaum R, Menachery VD. 2020. SARS-CoV-2 is sensitive to type I interferon pretreatment. J Virol. 2020 Sep 16;JVI.01410-20. PMID: 32938761


Gniadek TJ, Thiede JM, Matchett WE, Gress AR, Pape KA, Jenkins MK, Menachery VD, Langlois RA, Bold TD. 2020. SARS-CoV-2 neutralization and serology testing of COVID-19 convalescent plasma from donors with non-severe disease Transfusion. 2020 Sep 16. PMID: 32935872

Rostad CA, Chahroudi A, Mantus G, Lapp SA, Teherani M, Macoy L, Tarquinio KM, Basu RK, Kao C, Linman WM, Zimmerman MG, Shi PY, Menachery VD, Oster ME, Edupuganti S, Anderson EJ, Suthar M, Wrammert J, Jaggi P. Quantitative SARS-CoV-2 Serology in Children with Multisystem Inflammatory Syndrome (MIS-C). Pediatrics. 2020 Sep 2:e2020018242. PMID: 32879033

Muruato AE, Fontes-Garfias CR, Ren P, Garcia-Blanco MA, Menachery VD, Xie X, Shi PY. 2020. A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation. Nat Commun. 2020 Aug 13;11(1):4059. PMID: 32792628

Prasanth KR, Hirano M, Fagg WS, McAnarney ET, Shan C, Xie X, Hage A, Pietzsch CA, Bukreyev A, Rajsbaum R, Shi PY, Bedford MT, Bradrick SS, Menachery V, Garcia-Blanco MA. 2020. Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses. Antiviral Res. 2020 Jul 28;182:104874. PMID: 32735900

Vanderheiden A, Ralfs P, Chirkova T, Upadhyay AA, Zimmerman MG, Bedoya S, Aoued H, Tharp GM, Pellegrini KL, Manfredi C, Sorscher E, Mainou B, Lobb JL, Kohlmeier JE, Lowen AC, Shi PY, Menachery VD, Anderson LJ, Grakoui A, Bosinger SE, Suthar MS. Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures. J Virol. 2020;JVI.00985-20.  PMID: 32699094

Suthar MS, Zimmerman MG, Kauffman RC, Mantus G, Linderman SL, Hudson WH, Vanderheiden A, Nyhoff L, Davis CW, Adekunle O, Affer M, Sherman M, Reynolds S, Verkerke HP, Alter DN, Guarner J, Bryksin J, Horwath MC, Arthur CM, Saakadze N, Smith GH, Edupuganti S, Scherer EM, Hellmeister K, Cheng A, Morales JA, Neish AS, Stowell SR, Frank F, Ortlund E, Anderson EJ, Menachery VD, Rouphael N, Mehta AK, Stephens DS, Ahmed R, Roback JD, Wrammert J. 2020. Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients. Cell Reports Medicine 1:100040. 32835303

Sandler ZJ, Firpo MR, Omoba OS, Vu MN, Menachery VD, Mounce BC. Novel Ionophores Active against La Crosse Virus Identified through Rapid Antiviral Screening. Antimicrob Agents Chemother. 2020;64(6):e00086-20. PMID: 32284379

Lakdawala SS, Menachery VD. The search for a COVID-19 animal model. Science. 2020;368(6494):942-94.  PMID: 32467379
       
       Noll KE, Whitmore AC, West A, McCarthy MK, Morrison CR, Plante KS, Hampton BK, Kollmus H, Pilzner C, Leist SR, Gralinski LE, Menachery VD, Schäfer A, Miller D, Shaw G, Mooney M, McWeeney S, Pardo-Manuel de Villena F, Schughart K, Morrison TE, Baric RS, Ferris MT, Heise MT. 2020. Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross. Cell Rep 31:107587. PMID: 32348764

       Xie X, Muruato A, Lokugamage KG, Narayanan K, Zhang X, Zou J, Liu J, Schindewolf C, Bopp NE, Aguilar PV, Plante KS, Weaver SC, Makino S, LeDuc JW, Menachery VD*, Shi PY*. An Infectious cDNA Clone of SARS-CoV-2. Cell Host Microbe. 2020;27(5):841-848.e3. *Co-Senior Authors. PMID: 32289263

       Harcourt J, Tamin A, Lu X, Kamili S, Sakthivel SK, Murray J, Queen K, Tao Y, Paden CR, Zhang J, Li Y, Uehara A, Wang H, Goldsmith C, Bullock HA, Wang L, Whitaker B, Lynch B, Gautam R, Schindewolf C, Lokugamage KG, Scharton D, Plante JA, Mirchandani D, Widen SG, Narayanan K, Makino S, Ksiazek TG, Plante KS, Weaver SC, Lindstrom S, Tong S, Menachery VD*, Thornburg NJ*. Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with Coronavirus Disease, United States. Emerg Infect Dis. 2020;26(6):1266-1273. *Co-Senior Authors.  PMID: 32160149

       Gralinski LE, Menachery VD. Return of the Coronavirus: 2019-nCoV. Viruses. 2020 Jan 24;12(2). pii: E135. doi: 10.3390/v12020135.  PMID: 31991541 
 
       Menachery VD*, Dinnon KH*, Yount BL, McAnarney ET, Gralinski LE, Hale A, Graham RL, Scobey T, Anthony SJ, Corti D, Graham B, Lipkin WI, Baric RS.  Trypsin treatment unlocks barrier for zoonotic coronavirus infection. J. Virol. 2019 Dec 4. Pii: JVI.01774-19. doi: 10.1128/JVI.01774-19. PMID: 31801868
       
       Graham JB, Swarts JL, Menachery VD, Gralinski LE, Schaefer A, Plante K, Morrison C, Voss K, Green R, Choonoo G, Jeng S, Miller DR, Mooney M, McWeeney S, Ferris MT, Pardo Manuel de Villena F, Gale M, Baric RS, Heise M, Lund JM. Universal Immune Predictors of Mortality Following Virus Infection. J Infect Dis. 2019 Oct 17. pii: jiz531. PMID: 31621854

2019

Johnson BA, Hage A, Kalveram B, Mears M, Plante JA, Rodriguez SE, Ding Z, Bente D, Bradrick S, Freiberg AN, Popov V, Rajsbaum R, Rossi S, Russell WK, Menachery VD. Peptidoglycan associated cyclic lipopeptide disrupts viral infectivity. J Virol. 2019 Aug 28. pii: JVI.01282-19. doi: 10.1128/JVI.01282-19. PMID: 31462558

Dinnon KH, Gallichotte EN, Fritch EJ, Menachery VD, Baric RS. Shortening of Zika virus CD-loop reduces neurovirulence while preserving antigenicity. Plos Neglected Tropical Diseases. 2019 Mar 7; 13(3):e007212. PMID: 30845254.

Schindewolf C, Menachery VD. Middle East Respiratory Syndrome Vaccine Candidates: Cautious Optimism. Viruses. 2019 Jan 17; 11(1). Pii: E74. PMID: 30658390.

2018


Van Doremalen N, Schaefer A, Menachery VD, Letko M, Bushmaker T, Fischer R, Figueroa D, Hanley P, Saturday G, Baric RS, Munster V. SARS-like coronavirus WIV1-CoV does not replicate in Egyptian fruit bats (Rousettus aegyptiacus). Viruses. 2018 Dec 19; 10(12). Pii:E727. PMID: 30572566.

Gralinski LE, Sheahan TP, Morrison TE, Menachery VD, Jensen K, Whitmore A, Heise MT, Baric RS. Complement activation contributes to SARS-Coronavirus pathogenesis. MBio. 2018 Oct 9;9(5). pii: e01753-18. PMID: 30301856.

Van Doremalen N, Schaefer A, Menachery VD, Letko M, Bushmaker T, Fischer R, Figueroa D, Hanley P, Saturday G, Baric RS, Munster V. SARS-like coronavirus WIV1-CoV does not replicate in Egyptian fruit bats (Rousettus aegyptiacus). Viruses. 2018 Dec 19; 10(12). Pii:E727

Menachery VD, Gralinski LE, Mitchell HD, Dinnon KH, Leist SR, Yount BL, McAnarney ET, Graham RL, Waters KM, Baric RS.  Combination attenuation offers strategy for live-attenuated coronavirus vaccines. J Virol. 2018 Aug 16;92(17). pii: e00710-18. PMID: 29976657.

McMullan RC, Ferris MT, Bell TA, Menachery VD, Baric RS, Hua K, Pomp D, Smith-Ryan A, Pardo-Manuel de Vilena F. CC002/Unc females are mouse models of exercise-induced adverse fat response. Physiol Rep. 2018 Jun;6(12):e13716. PMID: 29924460.

Menachery VD*, Agnihothrum S, Yount BL, Lindesmith LC, Whitmore A, Schaefer A, Heise MT, Baric RS. Development of a broadly accessible VEE Replicon Particle Vaccine Platform. J. Virol. 2018 May 14;92(11). pii: e00027-18. *Co-first authors. PMID: 29540599.


Menachery VD, Schaefer A, Burnum-Johnson KE,Mitchell HD, Eisfeld AJ, Walters KB, Nocra CD, Purvine SO, Casey CP, Monroe ME, Weitz KK, Stratton KG, Webb-Robertson BM, Gralinski LE, Metz TO, Smith RD, Waters KM, Sims AC, Kawaoka Y, Baric RS. MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape. PNAS. 2018 Jan 30;115(5):E1012-E1021. PMID: 29339515Summary Prezi

Johnson BA, Graham RL, Menachery VD.  Metagenomics, structure, and reverse genetics: Key platforms for emerging coronavirus research. Virology. 2017 Dec 23. pii: S0042-6822(17)30414-2.  PMID: 29279138.

2017

Menachery VD, Gralinski LE, Dinnon KH, Mitchell HD, Dinnon KD, Leist SR, Yount BL, Graham RL, McAnarney ET, Stratton KG, Debbink K, Sims AC, Waters KM, Baric RS.  MERS-CoV NSP16 necessary for IFN resistance and viral pathogenesis. Msphere 2017. PMID: 29152578Summary Prezi

Gallichotte EN, Dinnon KH, Lim XN, Ng TS, Lim E, Menachery VD, Kok SM Lok, Baric RS. CD-loop extension in Zika virus envelope key for stability and pathogenesis. J Infect Dis. 2017 Sep 8. PMID 28968838

Menachery VD, Mitchell HD, Cockrell AS, Gralinski LE, Yount BL, Graham RL, McAnarney ET, Douglas MG, Scobey T, Beall A, Dinnon K, Kocher JF, Hale AE, Stratton KG, Waters KM, Baric RS. MERS-CoV Accessory ORFs play key role for infection and pathogenesis. MBio. 2017 Aug 22;8(4). pii: e00665-17. PMID 28830941.   Summary Prezi 

Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I, Bannister R, Park Y, Babusis D, Clarke MO, Mackman RL, Siegel D, Ray AS, Cihlar T, Jordan R, Denison MR, Baric RS. Broad-spectrum antiviral GS-5734 inhibit both epidemic and zoonotic coronavirus. Science Translation Medicine, 2017 Jun 28;9(396). pii: eaal3653. PMID 28659436.

Gralinski LE, Menachery VD, Morgan AP, Totura AL, Beall A, Kocher J, Plante J, Harrison-Shostak DC, Schaefer A, Pardo-Manuel de Vilena F, Ferris MT, Baric RS. Allelic Variation in Ticam2 contributes to SARS-CoV pathogenesis. G3 (Bethesda), 017 Jun 7;7(6):1653-1663. PMID 28592648.

Anthony SJ, Gilardi K, Menachery VD, Goldstein T, Ssebide B, Mbabazi R, Navarrete-Macias I, Liang E, Wells H, Hicks A, Petrosov A, Byarugaba DK, Debbink K, Dinnon KH, Scobey T, Randell SH, Yount BL, Cranfield M, Johnson CK, Baric RS, Lipkin WI, Mazet JAK. Further evidence for bats as the evolutionary source of MERS Coronavirus. MBio. 2017 Apr 4;8(2). pii: e00373-17. PMID 28377531.

Menachery VD*, Gallichotte EN*, Dinnon KH, Yount BL, Hartman S, Widman D, Messer W, de Silva A, Baric RS. Epitope Addition and Ablation via Manipulation of a Dengue Virus Serotype 1 Infectious Clone. mSphere. 2017 Feb 22;2(1). pii: e00380-16. *Co-first authors. PMID 28251184

Menachery VD, Graham RL, Baric RS. Jumping species – a mechanism for coronavirus survival. Current Opinion in Virology. 2017 Feb 16;23:1-7. PMID 28214731.

2016

Menachery VD, Yount BL, Sims AC, Agnihothram SA, Gralinski LE, Plante JA, Graham RL, Scobey T, Royal S, Pickles RJ, Randell SH, Lanzavecchia A, Marasco WA, Baric RS. SARS-like WIV1-CoV poised for human emergence, but may lack epidemic potential. PNAS. 2016 Mar 14. pii: 201517719. PMID 26976607.  

*Article Commentary by Vincent Racaniello: PMID 26976606

2015


Menachery VD.  MERS vaccine candidate offers promise, but questions remain. E-Biomedicine. Commentary. PMID 26629514.


Menachery VD, Yount BL, Debbink K, Agnihothrum SA, Gralinski LE, Graham RL, Plante JA, Scobey T, Donaldson E, Ge XY, Randell SH, Lanzavecchia A, Marasco WA, Shi ZL, Baric RS. SARS-like cluster of circulating bat coronaviruses pose a threat for human emergence. Nature Medicine. Dec;21 (12): 1508-13. PMID 26552008

Gralinski LE, Ferris MT, Aylor DL, Whitmore AC, Green R, Frieman M, Deming D, Menachery VD, Miller DR, Buus RJ, Bell TA, Churchill GA, Threadgill DW, Katze MG, McMillan L, Valdar W, Heise MT, Pardo-Manuel de Vilena F, Baric RS.  Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross. PlosGenetics. 2015 Oct 9; 11(10):e1005504.  PMID 26452100

Menachery VD, Gralinski LE, Baric RS, Ferris MT. New Metrics for Evaluating Respiratory Pathogenesis. PlosOne. 2015 June 26; 10(6): e0131451. PMID 26115403

2014

Selinger C, Tisoncik-Go J, Menachery VD, Agnihothrum S, Law GL, Chang J, Kelly SM, Sova P, Baric RS, Katze MG. Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates. BMC Genomics. 2014 Dec 22;15(1):1161.  PMID 25534508.

Menachery VD, Debbink K, Baric RS. Coronavirus Non-Structural Protein 16: Evasion, Attenuation, and Possible Treatments. Virus Research. 2014 Sep 30; pii: S0168-1702(14)00396-7. PMID 25278144.

Aevermann B, Pickett B, Kumar S, Klem E, Agnihothrum S, Askovich P, Bankhead A, Bolles M, Carter V, Chang J, Clauss T, Dash P, Diercks A, Eisfeld A, Ellis A, Fan S, Ferris M, Gralinski L, Green R, Gritsenko M, Hatta M, Heegel R, Jacobs J, Jeng S, Josset L, Kaiser S, Kelly S, Law G, Li C, Li J, Long C, Luna M, Matzke M, McDermott J, Menachery V, Metz T, Mitchell H, Monroe M, Navarro G, Neumann G, Podyminogin R, Purvine S, Rosenberger C, Sanders C, Schempmoes A, Shukla A, Sims A, Sova P, Tam V, Tchitchek N, Thomas P, Tilton S, Totrua A, Wang J, Webb-Robertson B, Wen J, Weiss J, Yang F, Yount B, Zhang Q, McWeeney S, Smith R, Water K, Kawaoka Y, Baric R, Aderem A, Katze M, Scheuermann R. A Comprehensive collection of systems biology data characterizing the host response to viral infection. Scientific Data.  2014 Oct. 14;1: 140033. PMID 25977790.

Menachery VD, Eisfeld AJ, Josset L, Sims AC, Schaefer A, Proll S, Fan S, Li C, Neumann G, Tilton SC, Chang J, Gralinski LE, Long C, Green R, Matzke MM, Webb-Robertson BJ, Shukula AK, Burkett S, Metz TO, Pickles R, Smith RD, Waters KM, Katze MG, Kawaoka Y, Baric RS. Pathogenic influenza and coron aviruses utilize similar and contrasting approaches to control global interferon stimulated gene responses. MBio. 2014 May 20; 5(3): e01174-14. PMID 24846384.

Agnihothram S, Yount BL Jr, Donaldson EF, Huynh J, Menachery VD, Gralinski LE, Graham RL, Becker MM, Tomar S, Scobey TD, Osswald HL, Whitmore A, Gopal R, Ghosh AK, Mesecar A, Zambon M, Heise M, Denison MR, Baric RS. A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant. MBio. 2014 Mar 25; 5(2): e00047-14. PMID 24667706.

Menachery VD, Yount BL, Josset L, Gralinski LE, Scobey T, Agnihothram S, Katze M, Baric RS. Attenuation and Restoration of SARS-CoV Mutant lacking 2’O Methyltransferase Activity. J Virol. 2014 Apr;88(8):4251-64. PMID 24478444.

2013

Agnihothram S, Gopal R, Yount B Jr, Donaldon EF, Menachery VD, Graham RL, Scobey TD, Gralinski LE, Denison MR, Zambon M, Baric RS. 2013. Evaluation of Serologic and Antigenic Relationships Between Middle Eastern Respiratory Syndrome Coronavirus and Other Coronaviruses to Develop Vaccine Platforms for the Rapid Response to Emerging Coronaviruses. J Infect Dis. 2013 Dec 30. PMID 24253287.

Scobey T, Yount BL, Sims AC, Donaldson EF, Agnihothram SS, Menachery VD, Graham RL, Swanstrom J, Bove PF, Kim JD, Grego S, Randell SH, Baric RS. Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16157-62. PMID 24043791.

Menachery VD, Baric RS. Bugs in the System. Immunol Rev. 2013 Sep: 255(1):256-74. PMID 2394736.

Gralinski LE, Bankhead A, Jeng S, Menachery VD, Proll S, Belisle SE, Matzke M, Webb-Robertson BJ, Luna ML, Shukla AK, Ferris MT, Bolles M, Chang J, Aicher L, Waters KM, Smith RD, Metz TO, Law GL, Katze MG, McWeeney S, Baric RS. Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury. MBio. 2013 Aug 6;4(4). PMID 23919993.

Menachery VD*, Josset L*, Gralinski LE, Agnihothram S, Sova P, Carter VS, Yount BL, Graham RL, Baric RS, Katze MG. Cell Host Response to Infection with Novel Human Coronavirus EMC Predicts Potential Antivirals and Important Differences with SARS Coronavirus. MBio. 2013 Apr 30; 4(3). *Co-first authors. PMID 23631916.

Sims AC, Tilton SC, Menachery VD, Gralinski LE, Schäfer A, Matzke MM, Webb-Robertson BJ, Chang J, Luna ML, Long CE, Shukla AK, Bankhead AR 3rd, Burkett SE, Zornetzer G, Tseng CT, Metz TO, Pickles R, McWeeney S, Smith RD, Katze MG, Waters KM, Baric RS. Release of SARS-CoV nuclear import block enhances host transcription in human lung cells. J Virol. 2013 Apr; 87(7):3885-902.  PMID 23365422.

2008-2012

Pasieka, TJ, Menachery VD, Rosato PC, Leib DA. Corneal replication is an interferon response-independent bottleneck for virulence of herpes simplex virus type 1 in the absence of virion host shutoff. J Virol. 2012 Jul; 86(14):7692-5.  PMID 22553331. 

Menachery VD, Pasieka TJ, Leib DA. Interferon regulatory factor 3-dependent pathways are critical for control of herpes simplex virus type 1 central nervous system infection. J Virol. 2010 Oct; 84(19): 9685-94. Epub 2010 Jul 21. PMID 20660188.

Menachery VD, Leib DA. Control of herpes simplex virus replication is mediated through an IRF-3 dependent pathway. J Virol. 2009 Dec; 83(23): 12399-406. PMID 19759149.

Pasieka TJ, Lu B, Crosby SD, Wylie KM, Morrison LA, Alexander DE, Menachery VD, Leib DA. Herpes simplex virus virion host shutoff attenuates establishment of the antiviral state. J Virol. 2008 Jun;82(11):5527-35. PMID 18367525.